Auflistung nach Autor "Tsezou, A."
Anzeige der Dokumente 1-20 von 113
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1,25-Dihydroxyvitamin D-3 and extracellular inorganic phosphate activate mitogen-activated protein kinase pathway through fibroblast growth factor 23 contributing to hypertrophy and mineralization in osteoarthritic chondrocytes
Orfanidou, T.; Malizos, K. N.; Varitimidis, S.; Tsezou, A. (2012)Hypertrophy and impaired mineralization are two processes closely associated with osteoarthritis (OA). 1,25-dihydroxyvitamin D-3 (1a,25(OH)(2)D-3) and inorganic phosphate (Pi) are two important factors that are implicated ... -
Absence of linkage to chromosomes 6q and 16p in a Greek population with knee osteoarthritis
Tsezou, A.; Karachalios, T.; Fytili, P.; Giannatou, E.; Christodoulou, K.; Hadjigeorgiou, G. M.; Malizos, K. N. (2006)Osteoarthritis (OA) is a common age-related debilitating disease of the joints characterized by degeneration of the articular cartilage which leads to joint pain, discomfort, and immobility. Several risk factors have been ... -
The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells
Palianopoulou, M.; Papanikolaou, V.; Stefanou, N.; Tsezou, A. (2011)Although leptin has been found to be implicated in obesity-related breast carcinogenesis in postmenopausal women, the molecular mechanisms involved are yet to be defined. Recently, the antiapoptotic gene survivin has been ... -
Angiopoietin 1 and 2 in failed pregnancy
Daponte, A.; Deligeoroglou, E.; Pournaras, S.; Tsezou, A.; Garas, A.; Skentou, H.; Messinis, I. E. (2012) -
Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion A case-control study
Daponte, A.; Deligeoroglou, E.; Pournaras, S.; Tsezou, A.; Garas, A.; Anastasiadou, F.; Hadjichristodoulou, C.; Messinis, I. E. (2013)Background: A case-control study to evaluate whether a single serum measurement of angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) at 6-8 weeks gestation can differentiate failed pregnancies, whether ectopic pregnancies ... -
THE arcOGEN CONSORTIUM: STAGE 1 OF A GENOME-WIDE ASSOCIATION SCAN FOR OSTEOARTHRITIS
Panoutsopoulou, K.; Southam, L.; Rayner, W.; Zhai, G.; Beazley, C.; Arden, N.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Olher, W.; Ralston, S.; Spector, T.; Valdes, A.; Wallis, G.; Wilkinson, M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F.; Bumpstead, S.; Cupples, A.; Day-Williams, A.; Dixon, K.; Dohertys, S.; Elliott, K.; Evangelou, E.; Felson, D.; Gomez-Reino, J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Hofman, A.; Hunt, S.; Ioannidis, J.; Jonsdottir, I.; Keen, R.; Kerkhof, H.; Kloppenburg, M.; Koller, N.; Lakenberg, N.; Lane, N.; Lee, A.; Meulenbelt, I.; Nevitt, M.; O'Neill, F.; Parimi, N.; Potter, S.; Rego-Perez, I.; Riancho, J.; Sherburn, K.; Slagboom, E.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Tsezou, A.; Uitterlinden, A.; van Meurs, J.; Watkins, B.; Wheeler, M.; Mitchelle, S.; Zhu, Y.; Zmuda, J.; Zeggini, E.; Loughlin, J.; Arc, Ogen Consortium (2010) -
Asporin and knee osteoarthritis in patients of Greek origin
Kaliakatsos, M.; Tzetis, M.; Kanavakis, E.; Fytili, P.; Chouliaras, G.; Karachalios, T.; Malizos, K.; Tsezou, A. (2006)Ostearthritis (OA) is characterized by focal areas of loss of the articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change and synovitis. The Asporin (ASPN) ... -
Assessment of Osteoarthritis Candidate Genes in a Meta-Analysis of Nine Genome-Wide Association Studies
Rodriguez-Fontenla, C.; Calaza, M.; Evangelou, E.; Valdes, A. M.; Arden, N.; Blanco, F. J.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; Esko, T.; Aleta, C. M. G.; Carnota, Jjgr; Helgadottir, H.; Hofman, A.; Jonsdottir, I.; Kerkhof, H. J. M.; Kloppenburg, M.; McCaskie, A.; Ntzani, E. E.; Ollier, W. E. R.; Oreiro, N.; Panoutsopoulou, K.; Ralston, S. H.; Ramos, Y. F.; Riancho, J. A.; Rivadeneira, F.; Slagboom, P. E.; Styrkarsdottir, U.; Thorsteinsdottir, U.; Thorleifsson, G.; Tsezou, A.; Uitterlinden, A. G.; Wallis, G. A.; Wilkinson, J. M.; Zhai, G. J.; Zhu, Y. Y.; Felson, D. T.; Ioannidis, J. P. A.; Loughlin, J.; Metspalu, A.; Meulenbelt, I.; Stefansson, K.; van Meurs, J. B.; Zeggini, E.; Spector, T. D.; Gonzalez, A.; arc, Ogen Consortium (2014)Objective. To assess candidate genes for association with osteoarthritis (OA) and identify promising genetic factors and, secondarily, to assess the candidate gene approach in OA. Methods. A total of 199 candidate genes ... -
ASSOCIATION OF A BMP5 MICROSATELLITE WITH KNEE OSTEOARTHRITIS
Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012) -
Association of a BMP5 microsatellite with knee osteoarthritis: case-control study
Rodriguez-Fontenla, C.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Loughlin, J.; Gonzalez, A. (2012)Introduction: We aimed to explore the involvement of a multiallelic functional polymorphism in knee osteoarthritis (OA) susceptibility as a prototype of possible genetic factors escaping GWAS detection. Methods: OA patients ... -
Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes
Rodriguez-Lopez, J.; Pombo-Suarez, M.; Loughlin, J.; Tsezou, A.; Blanco, F. J.; Meulenbelt, I.; Slagboom, P. E.; Valdes, A. M.; Spector, T. D.; Gomez-Reino, J. J.; Gonzalez, A. (2009)Objective: To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif proteases. Methods: Non-synonymous ... -
Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma
Abazis-Stamboulieh, D.; Oikonomou, P.; Papadoulis, N.; Panayiotidis, P.; Vrakidou, E.; Tsezou, A. (2007)Interleukin-1 (IL-1) is a cytokine involved in the maturation and proliferation of B cells and plays a significant role in the development of lytic bone lesions, a major clinical feature of multiple myeloma (MM) patients. ... -
Association of KLOTHO Gene Polymorphisms with Knee Osteoarthritis in Greek Population
Tsezou, A.; Furuichi, T.; Satra, M.; Makrythanasis, P.; Ikegawa, S.; Malizos, K. N. (2008)Based on the fact that klotho-deficient mice exhibit multiple aging phenotypes, including osteopenia and subchondral sclerosis of joints and on the recent observation that KLOTHO gene plays an important role in calcium/phosphate ... -
Association of renin-angiotensin system and natriuretic peptide receptor A gene polymorphisms with hypertension in a Hellenic population
Tsezou, A.; Karayannis, G.; Giannataou, E.; Papanikolaou, V.; Triposkiadis, F. (2008)Introduction. Hypertension results from the interaction of genetic and environmental factors. Since the renin-angiotensin and the natriuretic peptide systems contribute to blood pressure regulation, variations in the ... -
Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer
Tsezou, A.; Tzetis, M.; Gennatas, C.; Giannatou, E.; Pampanos, A.; Malamis, G.; Kanavakis, E.; Kitsiou, S. (2008)Genetic variation in genes involved in estrogen biosynthesis, metabolism and signal transduction have been suggested to play a role in breast cancer. To determine the possible contribution of genetic variation in the ESR1 ... -
Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis
Fytili, P.; Giannatou, E.; Papanikolaou, V.; Stripeli, F.; Karachalios, T.; Malizos, K.; Tsezou, A. (2005)Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). To elucidate the possible role of genetic variation in the estrogen receptors alpha and beta (ER-alpha, ER-beta) and androgen ... -
Association of the CALM1 core promoter polymorphism with knee osteoarthritis in patients of Greek origin
Poulou, M.; Kaliakatsos, M.; Tsezou, A.; Kanavakis, E.; Malizos, K. N.; Tzetis, M. (2008)Purpose: Osteoarthritis (OA) is characterized by focal areas of loss of articular cartilage in synovial joints, associated with varying degrees of osteophyte formation, subchondral bone change, and synovitis. The Calmodulin ... -
Association of the leptin gene with knee osteoarthritis susceptibility in a Han Chinese population: A case-control study
Qin, J.; Shi, D.; Dai, J.; Zhu, L.; Tsezou, A.; Jiang, Q. (2010)Previous studies have suggested that leptin works as a key regulator in the pathogenesis of osteoarthritis (OA), and genetic factors modulate OA. This study assessed the contribution of leptin gene (LEP) polymorphism(s) ... -
Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes
Papathanasiou, I.; Malizos, K. N.; Tsezou, A. (2012)Introduction: Events normally taking place in the terminal chondrocyte differentiation in the growth plate are also observed during osteoarthritis (OA) development, suggesting that molecules, such as Wnts and bone morphogenetic ... -
The c.504T > C (p.Asn168Asn) polymorphism in the ABCB4 gene as a predisposing factor for intrahepatic cholestasis of pregnancy in Greece
Kitsiou-Tzeli, S.; Traeger-Synodinos, J.; Giannatou, E.; Kaminopetros, P.; Roma, E.; Makrythanasis, P.; Tsezou, A. (2010)